Polynucleotides
Rejuvenate your skin at a cellular level with polynucleotides. This advanced treatment boosts collagen and enhances skin hydration for a naturally youthful glow.
Often referred to as 'The Salmon Sperm Facial'


At Delphi Wellness Clinic in Nottingham, we proudly offer Plinest® and NEWEST® by Mastelli—two advanced, clinically proven skin rejuvenation treatments that work with the body's natural repair mechanisms.
Plinest® polynucleotide therapy uses DNA fragments to boost collagen production, cellular repair, and hydration, enhancing skin elasticity, tone, and texture for a naturally youthful appearance. Plinest® stimulates fibroblast activity, which can help reduce fine lines, calm inflammation, and improve pigmentation. Results typically last between 6-9 months, offering natural-looking results without altering facial expressions.
NEWEST® builds on Plinest® by combining polynucleotides with hyaluronic acid (HA). This addition of HA enhances moisture retention and further boosts skin elasticity and density, making it ideal for those looking to address more advanced skin ageing concerns. NEWEST® is a perfect complement to other skin therapies, either as a standalone solution or to prepare the skin for additional aesthetic treatments.
Explore the rejuvenating benefits of Plinest® and NEWEST® polynucleotide therapies at our Nottingham clinic. Contact us today to book a consultation and discover how these science-backed treatments can restore and refresh your skin naturally.
Frequently Asked Questions
Plinest® and NEWEST® are non-surgical, injectable skin treatments developed by Mastelli to improve skin texture, hydration, and elasticity. While both treatments use polynucleotides to stimulate natural collagen production and cellular repair, NEWEST® also contains hyaluronic acid (HA) for enhanced skin hydration and firmness, making it ideal for more advanced skin rejuvenation needs.
Plinest® and NEWEST® polynucleotide therapies activate skin’s fibroblasts, promoting collagen synthesis and increasing elasticity. This helps reduce fine lines, even pigmentation, and create a natural glow. NEWEST®, with added hyaluronic acid, enhances skin hydration and density, offering further anti-aging benefits for a refreshed, youthful look.
These treatments can be used on multiple areas, including the face, neck, décolletage, body and hands. Plinest® can be used in the delicate under eye area too. Each treatment targets specific skin concerns, from fine lines to uneven skin tone, and can be customised and combined to suit individual needs.
Results typically last 6-9 months, depending on individual skin condition and lifestyle factors. Regular maintenance sessions are recommended every 6-12 months to sustain optimal results.
A course of Plinest® or NEWEST® usually involves three sessions spaced 3-4 weeks apart. For long-lasting results, it’s best to follow this initial course with maintenance sessions approximately every 6-12 months.
Side effects are minimal but may occasionally include slight redness, swelling, or bruising at the injection site. These effects usually resolve within a few days, making downtime minimal.
Unlike fillers or traditional anti-aging injectables, Plinest® and NEWEST® work by enhancing the body’s own skin regeneration processes through polynucleotides and in NEWEST®, hyaluronic acid. This approach results in a more natural-looking improvement without altering facial expressions.
Both treatments are highly effective, with Plinest® being suitable for general skin rejuvenation, and NEWEST® being ideal for additional hydration and skin density support due to its added HA component. A consultation can help determine the best option based on individual skin goals.
01
Anti-Ageing
Reduces pigmentation and evens out skin tone for a more radiant complexion.
02
Hydrates Skin
Increases the skin’s moisture retention, leading to a more plump and hydrated appearance.
03
Minimally Invasive
A safe, injectable treatment with minimal discomfort and no significant downtime.
Treatment Price List
Plinest/Newest:
Per Area
1 Session: £350
2 Sessions: £600
3 Sessions: £900
Depending on size of area and degree of skin damage (more product may be required): POA
Areas Include:
Under Eyes
Neck
Mid Face
Décolletage
(payment options available)
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Plinest Hair:
-Phase 1: A treatment every 7-14 days for 4 sessions.
-Phase 2: A treatment every 3-4 weeks for a further 4 sessions.
Prices per treatment session are from £300 depending on the size of area being treated.
We are able to offer a package price for the full 8 sessions following a personalised consultation.
(payment options available)